Chromatin Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include RUNX1 (T cell development TF), ZEB1 (T cell differentiation TF), KAT2B/PCAF (histone acetyltransferase), SMYD3 (histone methyltransferase), TOP2B (topoisomerase IIB, required for transcription of large genes), RAD51B (DNA repair/recombination), and NR3C2 (nuclear receptor). SOS1 and TIAM1 are GEFs regulating RAS/RAC signaling downstream of TCR. ARHGAP15 is a Rho GAP. The module is tightly coherent with all genes showing core membership. The combination of chromatin-modifying enzymes (KAT2B, SMYD3), key MAIT/T cell transcription factors (RUNX1, ZEB1), and DNA topology enzymes (TOP2B, RAD51B) indicates an active chromatin remodeling and transcriptional regulation program. This pattern is consistent with a differentiation or activation-associated epigenetic regulatory state in MAIT cells.
Genes
ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA, IMMP2L, KAT2B, NR3C2, RAD51B, RUNX1, SCFD2, SLC9A9, SMYD3, SOS1, TIAM1, TMEM131L, TOP2B, VPS13B, ZEB1
Most correlated modules
- Calcineurin-NFAT Signaling · correlation 0.91
- Lymphocyte Migration · correlation 0.88
- Cytoskeletal Migration · correlation 0.83
- Cytoskeletal Migration · correlation 0.78
- SWI/SNF Chromatin Remodeling · correlation 0.76
- Immune Synapse Signaling · correlation 0.76
- RAS-GEF Signaling · correlation 0.75
- Naive T cell · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.