AKR1C3 — Aldo-keto reductase family 1 member C3
AKR1C3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKR1C3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Stress Signaling Inflammation | ELK4, EPS15, METRNL, MYCBP2, NFAT5, PALM, PELI2, PGM5 +4 more | View in SCUBA |
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | ASCL2, BFSP1, CARNS1, CD320, CES1, CMKLR1, CTBP2, CXCR1 +21 more | |
| Goblet cells | Epithelial Differentiation Metabolism Epithelial development | BSG, GOLM1, PKM, PRSS3, TMEM45B, TMEM54, TSPAN8 | View in SCUBA |
| Lymphatic endothelial | Hypoxia HIF Response Stress | AKR1C1, AKR1C2, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS, EGLN3 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | NK-like Cytotoxic cytotoxicity | BNC2, CLIC3, CX3CR1, FCGR3A, FGFBP2, GNLY, IGFBP7, KIR3DL1 +3 more | |
| Natural Killer cells | Cytotoxic NK Maturation Cytotoxicity | ADGRG1, CXCR2, FCGR3A, FGFBP2, GK5, LGR6, MTSS1, PRF1 +4 more | View in SCUBA |
About the gene
| Synonyms | DDX, HAKRB, HSD17B5, KIAA0119, PGFS |
|---|---|
| Chromosome | 10: 5035354-5107686 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 17- ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also displays retinaldehyde reductase activity toward 9-cis-retinal.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.