Mucosal MAIT Homing

Gene co-expression module in Mucosal-associated invariant T cell

Why this annotation

CCR6 is a hallmark chemokine receptor for mucosal/Tc17-like MAIT cell homing. FUT7 encodes a fucosyltransferase that generates selectin ligands (e.g., PSGL-1) critical for mucosal trafficking. SCART1 is expressed on γδ T and MAIT cells with tissue-homing properties. BLK is expressed in MAIT cells and linked to their unique developmental program. LGALS3 (galectin-3) modulates T cell adhesion and migration. PDCD4 is a translational repressor associated with Th17/regulatory states. The moderate coherence and many weak members reflect a mixed but predominantly mucosal-homing MAIT identity signature with some Tc17-like features.

Genes

BLK, BRD9, CCR6, DSEL, ERN1, FUT7, LGALS3, LPAR6, LST1, PDCD4, PI16, RCBTB2, SCART1, SYTL2

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.