CCR6 — C-C motif chemokine receptor 6
CCR6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chemokine Migration migration & adhesion | CYTIP, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E, PDE4B +7 more | View in SCUBA |
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR, IL23R +10 more | |
| Innate lymphoid cells | NK ILC Tissue Homing Homing & TEM | ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mucosal MAIT Homing migration & adhesion | BLK, BRD9, DSEL, ERN1, FUT7, LGALS3, LPAR6, LST1 +5 more |
About the gene
| Synonyms | BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22 |
|---|---|
| Chromosome | 6: 167111807-167139141 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.