SYTL2 — Synaptotagmin like 2
SYTL2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYTL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 more | View in SCUBA |
| Goblet cells | Golgi-Exocytosis Machinery Mucus production & secretion | BCAS1, GALNT5, GOLGA2, GOLGA3, MIA3, MLPH, PLA2G10, RRBP1 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mucosal MAIT Homing migration & adhesion | BLK, BRD9, CCR6, DSEL, ERN1, FUT7, LGALS3, LPAR6 +5 more | |
| Natural Killer cells | Gut-Homing NK Maturation Gut residency | ANXA2, BIN1, DHRS7, HECA, IFI27L2, ITGB7, KLF9, LGALS1 +5 more | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A +11 more | View in SCUBA |
| Smooth muscle cells | TGFB-Collagen Remodeling ECM remodeling | COL14A1, IGFBP2, LASP1, TGFB3, TPM3, VASN, VGLL3 | View in SCUBA |
About the gene
| Synonyms | CHR11SYT, exophilin-4, FLJ20163, FLJ21219, KIAA1597, MGC102768, PPP1R151, SGA72M, SLP2 |
|---|---|
| Chromosome | 11: 85694224-85811159 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Exocytosis |
Function
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.