Mitochondrial Quality Control
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
LETM2 is a mitochondrial inner membrane protein involved in mitochondrial morphology and ion homeostasis. COQ7 encodes a hydroxylase in the coenzyme Q (ubiquinone) biosynthesis pathway, essential for mitochondrial electron transport. YME1L1 is an inner mitochondrial membrane AAA-protease involved in mitochondrial quality control and protein processing. SDR42E2 is a short-chain dehydrogenase/reductase, likely mitochondrial or metabolic. These four genes form a coherent mitochondrial biosynthesis and quality control program. ZBTB10 (zinc finger TF), EPS8 (actin/receptor signaling), PATL2 (RNA regulation), and TBCC (tubulin cofactor) are less clearly linked and may represent peripheral members. The mitochondrial core (LETM2, COQ7, YME1L1, SDR42E2) is the defining feature. Neighbor context: adjacent to M113 (heat shock/proteostasis) which also has mitochondrial stress relevance, supporting mitochondrial quality control as the shared theme.
Genes
COQ7, EPS8, LETM2, PATL2, SDR42E2, TBCC, YME1L1, ZBTB10
Most correlated modules
- Dissociation Stress Response · correlation 0.75
- T cell Activation · correlation 0.72
- TCR-Induced Early Response · correlation 0.69
- AP-1 Immediate Early · correlation 0.67
- T cell Homeostasis · correlation 0.62
- MAIT Cell Identity · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.