TCR-Induced Early Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
NR4A1 (Nur77) is a nuclear receptor rapidly induced by TCR signaling and serves as a sensitive reporter of TCR activation strength. EGR1, ATF3, and IER3 are immediate early transcription factors induced by TCR/stress signals. TNF is a key effector cytokine produced by activated MAIT cells. RHOB is a Rho GTPase upregulated during T cell activation and stress. PPP1R15B (CReP) regulates eIF2α phosphorylation under stress. HMGCS1 encodes HMG-CoA synthase (cholesterol synthesis), which is upregulated during T cell activation. GLA (alpha-galactosidase A) and NUP58 (nuclear pore) are less clearly linked. TRA2B is a splicing factor. The dominant signature of NR4A1, EGR1, ATF3, IER3, TNF pointing to TCR-triggered immediate early transcriptional response. Neighbor context: shares immediate early genes with M110 and M97 but NR4A1 and TNF give this module a more specific TCR-activation identity.
Genes
ATF3, EGR1, GLA, HMGCS1, IER3, NR4A1, NUP58, PPP1R15B, RHOB, TNF, TRA2B, TSPYL4
Most correlated modules
- T cell Activation · correlation 0.91
- Heat Shock Response · correlation 0.81
- NF-κB Effector Activation · correlation 0.78
- Dissociation Stress Response · correlation 0.75
- Splicing Regulation · correlation 0.74
- Mitochondrial Quality Control · correlation 0.69
- MAIT Cell Identity · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.