T cell Homeostasis
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 28 genes have a known function matching the annotation |
Why this annotation
Key genes: SLAMF1 (SLAM family receptor, T/NK cell costimulation), LY9 (SLAM family, lymphocyte activation), FCMR (IgM Fc receptor, expressed on T/B cells), IL7R (IL-7 receptor, essential for T cell homeostasis and naïve T cell survival), CD40LG (CD40L, T helper effector function), GPR171 (neuropeptide receptor expressed in lymphocytes), ISG20/IFIH1 (interferon-stimulated genes), APOL6 (IFN-stimulated), TRIM14 (innate immune), TAP2 (antigen presentation), PML (IFN/antiviral), ZBTB25 (transcriptional repressor), SERINC3. The SLAM family receptors (SLAMF1, LY9), IL7R, and CD40LG together define a T cell homeostasis/activation module. ISG20, IFIH1, APOL6, PML, TAP2 add a mild interferon flavor. This strongly resembles a naïve/resting MAIT cell identity module with lymphocyte costimulatory markers and partial ISG signature.
Genes
APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R, ISG20, JAML, KCNA3, LY9, MKNK1, MT2A, NAP1L4, OGFR, PML, PPM1K, RORC, SERINC3, SLAMF1, SLC39A10, SPATS2L, TAF7, TAP2, TRAT1, TRIM14, ZBTB25
Most correlated modules
- IL-12 Cytotoxic Effector · correlation 0.80
- T cell Activation Signaling · correlation 0.74
- TCR Signaling Identity · correlation 0.71
- Type I Interferon · correlation 0.67
- Circadian Transcriptional Regulation · correlation 0.67
- Mitochondrial Quality Control · correlation 0.62
- Innate Stress Activation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.