Dissociation Stress Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SRSF7 and SRSF3 are SR-family splicing factors, but their co-expression with immediate early stress response genes FOS, IER5, DUSP1, and SAT1 suggests this module reflects acute cellular stress with concurrent splicing regulation changes. FOS, IER5, and DUSP1 are hallmark dissociation/mechanical stress genes. EIF1 (translation initiation) and H3-3B (histone variant) are consistent with a global transcriptional/translational stress response. This combination is characteristic of ex vivo isolation stress in single-cell experiments. Neighbor context: this module is adjacent to M97 and M116 which also carry immediate early gene signatures, reinforcing a stress-activation continuum.
Genes
DUSP1, EIF1, FOS, H3-3B, IER5, SAT1, SRSF3, SRSF7
Most correlated modules
- T cell Activation · correlation 0.90
- NF-κB Negative Feedback · correlation 0.89
- Integrated Stress Response · correlation 0.89
- ER Stress UPR · correlation 0.86
- Heat Shock Response · correlation 0.86
- mRNA Decay Program · correlation 0.83
- AP-1 Immediate Early · correlation 0.81
- RNA Processing Stress · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.