ER Stress Response
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include CREB3L1 (ER stress transcription factor, unfolded protein response in secretory cells), RNF145 (E3 ubiquitin ligase involved in ER-associated degradation/cholesterol sensing), VSIR (V-domain Ig suppressor of T-cell activation, immune checkpoint), HIPK2 (homeodomain-interacting protein kinase 2, stress/apoptosis/p53 regulation), NCOA3 (nuclear receptor coactivator 3, transcriptional coactivation), RNF19A (E3 ubiquitin ligase), RAB5B (endosomal trafficking), FNBP1 (formin-binding, actin), FLNB (filamin B, cytoskeletal), PARM1 (prostate androgen-regulated mucin-like), PRSS23 (serine protease), RFTN1 (raft endosomal). CREB3L1 is a strong ER stress/UPR marker in secretory cells. RNF145 and RNF19A suggest ubiquitin-mediated protein quality control. VSIR adds an immune modulatory dimension. The module is negatively associated with CD treatment response. The combination of ER stress, ubiquitin ligases, and immune checkpoint suggests an ER stress/protein quality control program, possibly in a secretory M-like cell state.
Genes
Most correlated modules
- Actin-mediated Migration · correlation 0.99
- Cytoskeletal Contractility · correlation 0.98
- Metabolic Homeostasis · correlation 0.98
- Stem-like Regenerative · correlation 0.96
- Metabolic Bioenergetics · correlation 0.96
- Integrated Stress Response · correlation 0.95
- Cellular Homeostasis · correlation 0.89
- Immediate Early Stress · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.