Cellular Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
This module contains COX7A2 (mitochondrial cytochrome c oxidase subunit), HSPD1 (mitochondrial chaperone HSP60), TXNIP (thioredoxin-interacting protein, metabolic/redox sensor), CALM2 (calmodulin, calcium signaling), ARPC3 (actin branching), DSTN (actin depolymerization), CLTB (clathrin-mediated endocytosis), ARF4 (vesicle trafficking), NPM1 (nucleolar protein, ribosome biogenesis), EIF4G2 (translation initiation), DSP (desmoplakin, cell junction), and TSPAN8 (tetraspanin). The module is broadly expressed (78.7% pct positive, uniform across subsets) and decreases with inflammation in both UC and CD, recovering with CD treatment. The mix of mitochondrial, cytoskeletal, trafficking, and translation genes suggests a general housekeeping/cellular homeostasis program. The top hub COX7A2 and HSPD1 point toward mitochondrial function, but the overall gene set is too mixed for a pure mitochondrial label. The dominant theme across the most concordant genes is cellular homeostasis encompassing mitochondrial respiration, cytoskeletal dynamics, and vesicle trafficking — consistent with a housekeeping program that is suppressed during active inflammation.
Genes
Most correlated modules
- Metabolic Bioenergetics · correlation 0.96
- Cytoskeletal Contractility · correlation 0.94
- Actin-mediated Migration · correlation 0.92
- Stem-like Regenerative · correlation 0.91
- Immediate Early Stress · correlation 0.90
- Metabolic Homeostasis · correlation 0.89
- ER Stress Response · correlation 0.89
- Mitochondrial OxPhos · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.