Metabolic Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include GPI (glucose-6-phosphate isomerase, glycolysis), ODC1 (ornithine decarboxylase, polyamine synthesis/proliferation), ESRRA (estrogen-related receptor alpha, metabolic transcription factor), PTP4A1 (phosphatase promoting cell growth), ITGA6 (integrin alpha-6, stemness/adhesion), NFIB (transcription factor), ARL4A (GTPase), PSMD14 (proteasome), TCEA1 (transcription elongation). The module is negatively associated with inflammation in both UC and CD, and positively with CD treatment response. The combination of metabolic enzymes (GPI, ODC1), a metabolic master regulator (ESRRA), a stemness-associated integrin (ITGA6), and growth-promoting phosphatase (PTP4A1) suggests a basal metabolic/homeostatic program linked to cell maintenance and mild proliferative capacity. SIVA1 is a pro-apoptotic gene but also involved in cell survival signaling. The uniform expression across subsets and core coherence support a housekeeping-like metabolic program.
Genes
Most correlated modules
- Actin-mediated Migration · correlation 0.99
- Stem-like Regenerative · correlation 0.98
- ER Stress Response · correlation 0.98
- Cytoskeletal Contractility · correlation 0.98
- Metabolic Bioenergetics · correlation 0.98
- Integrated Stress Response · correlation 0.96
- Cellular Homeostasis · correlation 0.89
- Immediate Early Stress · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.