Stem-like Regenerative
Gene co-expression module in Microfold-like cells
| Category | Stemness |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SOX9 (master transcription factor for intestinal stem/progenitor cells and secretory lineage), STAT3 (JAK-STAT signaling, proliferation/survival/inflammation), ETS2 (ETS transcription factor, differentiation/stress response), TOB1 (anti-proliferative, growth arrest), SRSF2 (splicing factor), DNAJB1 (heat shock chaperone), GSTK1 (glutathione transferase, stress), MIDN (midnolin, proteasome-related), SLC12A2 (NKCC1, ion transport). SOX9 and STAT3 together strongly suggest a progenitor/stem-like or regenerative state. SOX9 is a key marker of intestinal stem cells and transit-amplifying cells; STAT3 is activated in regenerative and inflammatory contexts. The module is positively associated with remission in UC and CD treatment response. This combination points to a regenerative/stem-like transcriptional program, consistent with M-like cell plasticity toward a progenitor state.
Genes
Most correlated modules
- Metabolic Bioenergetics · correlation 0.99
- Cytoskeletal Contractility · correlation 0.98
- Metabolic Homeostasis · correlation 0.98
- Actin-mediated Migration · correlation 0.97
- Integrated Stress Response · correlation 0.96
- ER Stress Response · correlation 0.96
- Immediate Early Stress · correlation 0.92
- Cellular Homeostasis · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.