Immediate Early Stress
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are BTG1 (anti-proliferative, stress response), PPP1R15A (GADD34, integrated stress response/UPR), IER3 (immediate early gene, stress/NF-κB), FOS and JUN (AP-1 transcription factors, immediate early genes), EGR1 (immediate early transcription factor), NFKBIA (NF-κB inhibitor, stress/inflammatory response), SQSTM1 (p62, autophagy/stress), ZFP36L2 (mRNA stability, stress), HSPA8 and HSP90AA1 (heat shock chaperones), SAT1 (polyamine catabolism, stress), RHOB (Rho GTPase, stress-induced), CTNND1 (p120-catenin, cell adhesion), SON (splicing), ARGLU1 (transcriptional coactivator), P4HB (ER chaperone/disulfide isomerase), TUBA1B (tubulin), MUC12 (mucin), S100A14 (calcium-binding). The module is dominated by immediate early genes and stress-response transcription factors (FOS, JUN, EGR1, IER3, BTG1, PPP1R15A/GADD34, NFKBIA), consistent with a dissociation/cellular stress response or in vivo acute stress program. It decreases with UC inflammation and recovers with remission, suggesting it marks a baseline stress-adaptive state lost during active disease. The neighbor context (M74 also has immediate early genes JUNB, FOSB, IER2, NR4A1) strongly supports this being a stress/immediate early gene program rather than a specific inflammatory activation.
Genes
Most correlated modules
- Cytoskeletal Contractility · correlation 0.92
- Stem-like Regenerative · correlation 0.92
- Metabolic Bioenergetics · correlation 0.91
- Cellular Homeostasis · correlation 0.90
- Integrated Stress Response · correlation 0.88
- Actin-mediated Migration · correlation 0.85
- Metabolic Homeostasis · correlation 0.85
- Mitochondrial OxPhos · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.