Cytoskeletal Contractility
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include NOXO1 (NADPH oxidase organizer 1, ROS production), MYH9 (non-muscle myosin IIA, cytoskeletal/contractility), TPM1 (tropomyosin 1, actin filament stabilization), MISP (mitotic spindle positioning, actin cortex), UBE2D3 (ubiquitin conjugating enzyme), SRRM1 (splicing), MGAT4B (glycosyltransferase), PLXNB2 (semaphorin receptor, cytoskeletal signaling), SDC4 (syndecan-4, adhesion/signaling), FOSL2 (AP-1 transcription factor, inflammatory/stress), IGKC (immunoglobulin kappa constant — likely contamination or ambient). The module is positively associated with UC inflammation. The core theme is cytoskeletal organization with an oxidative/inflammatory overlay: NOXO1 drives ROS, MYH9/TPM1/MISP are cytoskeletal, FOSL2 is an AP-1 factor activated by stress/inflammation, SDC4 and PLXNB2 link to signaling. IGKC is likely ambient B-cell RNA. Overall this represents a cytoskeletal/contractile program with inflammatory activation.
Genes
Most correlated modules
- Actin-mediated Migration · correlation 0.99
- Metabolic Bioenergetics · correlation 0.99
- ER Stress Response · correlation 0.98
- Stem-like Regenerative · correlation 0.98
- Metabolic Homeostasis · correlation 0.98
- Integrated Stress Response · correlation 0.96
- Cellular Homeostasis · correlation 0.94
- Immediate Early Stress · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.