Actin-mediated Migration
Gene co-expression module in Microfold-like cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include WASL (N-WASP, actin nucleation/cytoskeletal remodeling), CDC42 (Rho GTPase master regulator of actin dynamics), NEDD9 (scaffold for focal adhesion/migration), ITGA3 (integrin alpha-3, adhesion), SH3GLB1 (endophilin B1, membrane dynamics/autophagy), TMEM230 (vesicle trafficking), RAB32 (Rab GTPase, vesicle trafficking), CLNS1A (chloride channel), RIOK3 (kinase), SARAF (calcium regulation), PLPP2 (lipid phosphatase). The dominant theme is actin cytoskeleton regulation and cell migration: CDC42 and WASL are canonical actin polymerization regulators, NEDD9 and ITGA3 are migration/adhesion effectors. This module likely reflects a migratory or cytoskeletal remodeling state in M-like cells.
Genes
Most correlated modules
- Metabolic Homeostasis · correlation 0.99
- ER Stress Response · correlation 0.99
- Cytoskeletal Contractility · correlation 0.99
- Metabolic Bioenergetics · correlation 0.98
- Stem-like Regenerative · correlation 0.97
- Integrated Stress Response · correlation 0.94
- Cellular Homeostasis · correlation 0.92
- Immediate Early Stress · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.