Integrated Stress Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include PABPC4 (poly(A)-binding protein cytoplasmic 4, mRNA stability/translation), IER5 (immediate early response gene 5, stress/heat shock response), HEXIM1 (hexamethylene bisacetamide inducible 1, P-TEFb inhibitor regulating transcription elongation), SLC38A2 (amino acid transporter, nutrient sensing/mTOR), YME1L1 (mitochondrial AAA protease, mitochondrial quality control), PCK1 (phosphoenolpyruvate carboxykinase 1, gluconeogenesis/metabolic stress), MAML2 (mastermind-like 2, Notch transcriptional coactivator), MUC1 (mucin 1, epithelial surface). The module is strongly positively associated with CD inflammation and negatively with CD treatment. IER5 and HEXIM1 together suggest a transcriptional stress response (P-TEFb regulation). SLC38A2 is induced by amino acid deprivation (integrated stress response). PCK1 is a metabolic stress gene. MAML2 links to Notch signaling. This module resembles an integrated stress response / nutrient-sensing program activated in CD inflammation.
Genes
Most correlated modules
- Stem-like Regenerative · correlation 0.96
- Metabolic Homeostasis · correlation 0.96
- Cytoskeletal Contractility · correlation 0.96
- ER Stress Response · correlation 0.95
- Actin-mediated Migration · correlation 0.94
- Metabolic Bioenergetics · correlation 0.93
- Immediate Early Stress · correlation 0.88
- Cellular Homeostasis · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.