Metabolic Bioenergetics
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include BSG (basigin/CD147, glycoprotein facilitating MCT lactate transporters and matrix metalloproteinase induction), LDHA (lactate dehydrogenase A, aerobic glycolysis/Warburg), NDUFS7 and NDUFC1 (NADH:ubiquinone oxidoreductase subunits, Complex I of mitochondrial ETC), SOD1 (superoxide dismutase, antioxidant), PHB2 (prohibitin 2, mitochondrial integrity), DNAJA1 (HSP40 chaperone), TUBB4B (tubulin), LIMA1 (actin-associated), NUCKS1 (chromatin/proliferation), TPD52 (tumor protein D52, proliferation/vesicle trafficking), SEC61G (ER translocon), ANP32B (chromatin/apoptosis), SRSF11 (splicing). The module combines glycolytic (BSG, LDHA) and mitochondrial (NDUFS7, NDUFC1, PHB2, SOD1) genes, suggesting a mixed metabolic program. BSG-LDHA co-expression is a hallmark of the Warburg/glycolytic phenotype, while the NADH dehydrogenase subunits and PHB2 reflect mitochondrial activity. This may represent a metabolic flexibility or bioenergetic housekeeping module. Negatively associated with UC inflammation, positively with CD treatment.
Genes
Most correlated modules
- Cytoskeletal Contractility · correlation 0.99
- Stem-like Regenerative · correlation 0.99
- Actin-mediated Migration · correlation 0.98
- Metabolic Homeostasis · correlation 0.98
- Cellular Homeostasis · correlation 0.96
- ER Stress Response · correlation 0.96
- Integrated Stress Response · correlation 0.93
- Immediate Early Stress · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.