Proteasome Proteolysis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes PSME1, PSMA7, PSMB1 are proteasome subunits (20S core and regulatory), CTSS is a lysosomal cysteine protease, PARK7 is a redox-regulated protease/chaperone, DAD1 is an anti-apoptotic component of the oligosaccharyltransferase complex, GLRX5 supports iron-sulfur cluster assembly, ATP5F1A and MRPL20 reflect mitochondrial housekeeping. The module is dominated by ubiquitin-proteasome system and lysosomal proteolysis genes. Uniform expression, negative correlation with inflammation, and restoration with treatment are consistent with constitutive protein quality control suppressed during inflammatory stress.
Genes
Most correlated modules
- ER Cotranslational Processing · correlation 1.00
- Metabolic Housekeeping · correlation 1.00
- OxPhos Complex IV · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Mitochondrial OxPhos · correlation 0.99
- Complex I Assembly · correlation 0.99
- Membrane Trafficking · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.