ER & Mitochondrial Maintenance
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF2S2 (translation initiation factor), GHITM (mitochondrial membrane protein), VDAC2 (mitochondrial outer membrane voltage-dependent anion channel), PRKACB (cAMP-dependent protein kinase catalytic subunit), SNX3 (sorting nexin, vesicle trafficking), SNRPG (snRNP splicing), KDELR1 (ER retention receptor), and RER1 (ER retrieval/retention). The module combines ER/protein trafficking (KDELR1, RER1, SNX3), mitochondrial membrane (VDAC2, GHITM), translation (EIF2S2), and splicing (SNRPG). Uniform expression, all core members, decreased in inflammation and restored by CD treatment — consistent with constitutive housekeeping/cellular maintenance. Neighbor context (M45, M42) confirms a cluster of housekeeping modules. The ER and mitochondrial membrane components are prominent, suggesting protein processing and organelle maintenance.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 1.00
- Housekeeping Mixed · correlation 1.00
- Mitochondrial OxPhos · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Protein Homeostasis · correlation 0.99
- Protein Processing ER · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.