ER Cotranslational Processing
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
SEC11A encodes the catalytic subunit of the signal peptidase complex (ER co-translational processing); EIF3H is a translation initiation factor; SF3B6 is a spliceosome component; UFC1 is the E2 enzyme for UFMylation (ER stress-linked ubiquitin-like modification); LAMTOR5 is part of the Ragulator/mTORC1 lysosomal complex; UQCRC2 and ATP5F1C are mitochondrial respiratory chain subunits; COMMD6 is involved in copper metabolism and NF-κB regulation. The module blends ER co-translational processing, translation, and mitochondrial housekeeping — a general cellular maintenance signature. Neighbor context with M1 (proteasome) and M65 (OxPhos/translocon) supports a housekeeping cluster.
Genes
Most correlated modules
- Proteasome Proteolysis · correlation 1.00
- Mitochondrial OxPhos · correlation 1.00
- OxPhos Complex IV · correlation 1.00
- Translation Initiation · correlation 1.00
- Organelle Homeostasis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.