Membrane Trafficking
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include CLTA (clathrin light chain, endocytosis), VDAC1 (mitochondrial voltage-dependent anion channel), SMIM14 (small integral membrane protein), DNAJC15 (mitochondrial DnaJ co-chaperone), VPS29 (retromer complex, endosomal sorting), MGST1 (microsomal glutathione S-transferase), PSMA1 (proteasome subunit), RAB2A (vesicle trafficking GTPase), OCIAD1 (mitochondria-associated), PDIA3 (ER protein disulfide isomerase), SPCS2 (signal peptidase complex), REEP5 (ER shaping), YWHAB (14-3-3 protein, signaling scaffold), SRI (sorcin, calcium-binding), UBE2B (ubiquitin-conjugating enzyme), ADH5 (alcohol dehydrogenase). All are core members with uniform expression. This module spans vesicle trafficking (CLTA, VPS29, RAB2A), ER function (PDIA3, SPCS2, REEP5), mitochondria (VDAC1, DNAJC15, OCIAD1), and proteasome (PSMA1, UBE2B). Like M52, it is downregulated in inflammation and recovers with treatment, consistent with constitutive housekeeping programs. The neighbor relationship with M52 (also housekeeping/protein homeostasis) supports this classification. This module emphasizes intracellular membrane trafficking and organelle maintenance.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 1.00
- Organelle Homeostasis · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- Intracellular Cargo Transport · correlation 0.99
- Apoptosis Regulation · correlation 0.99
- Protein Homeostasis · correlation 0.99
- Complex I Assembly · correlation 0.99
- Epithelial Identity · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.