Mitochondrial OxPhos
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SF3B5 (spliceosome SF3B complex), COX5A (cytochrome c oxidase subunit, complex IV), NOP10 (H/ACA snoRNP, ribosome biogenesis), PCBD1 (pterin-4-alpha-carbinolamine dehydratase, cofactor recycling), ATP5PO and ATP5PB (ATP synthase subunits, complex V), MDH2 (malate dehydrogenase, TCA cycle), NDUFA8 and NDUFB9 (NADH dehydrogenase complex I subunits). The module is strongly enriched for mitochondrial oxidative phosphorylation components (COX5A, ATP5PO, ATP5PB, MDH2, NDUFA8, NDUFB9) alongside splicing (SF3B5) and ribosome biogenesis (NOP10). The OxPhos genes dominate by count and function. Decreased in inflammation, restored by CD treatment — consistent with metabolic housekeeping suppressed during inflammatory stress. Neighbor modules M9 and M42 also contain OxPhos genes, confirming a neighborhood of mitochondrial/housekeeping programs.
Genes
Most correlated modules
- ER Cotranslational Processing · correlation 1.00
- ER & Mitochondrial Maintenance · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- Mitochondrial OxPhos · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Translation Initiation · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.