Metabolic Housekeeping
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSMB2 (proteasome beta subunit), DLD (dihydrolipoamide dehydrogenase, mitochondrial TCA/KGDH complex), MDH1 (malate dehydrogenase, cytosolic TCA-linked), PPA2 (mitochondrial pyrophosphatase), ALDH2 (aldehyde dehydrogenase, mitochondrial), LGALS3BP (galectin-3 binding protein), PPP1R14D (protein phosphatase regulatory subunit), LSM5 (RNA splicing/processing), OLA1 (GTPase, translation regulation). All are core members with uniform expression. The module mixes metabolic enzymes (DLD, MDH1, ALDH2, PPA2 — all mitochondrial or metabolic), proteasome (PSMB2), and RNA processing (LSM5). The strong downregulation in CD inflammation and recovery with CD treatment mirrors M52 and M101. Given the neighbor context of housekeeping modules, this represents constitutive metabolic/housekeeping programs. The mitochondrial metabolic enzymes are the dominant theme. Concordant metabolic/housekeeping genes: PSMB2, DLD, MDH1, PPA2, ALDH2, LSM5, OLA1, LGALS3BP, PPP1R14D.
Genes
Most correlated modules
- ER & Mitochondrial Maintenance · correlation 1.00
- Membrane Trafficking · correlation 1.00
- Proteasome Proteolysis · correlation 1.00
- Protein Homeostasis · correlation 0.99
- ER Membrane Trafficking · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
- Complex I Assembly · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.