Complex I Assembly
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
NDUFV2, NDUFC2, and DMAC1 are Complex I subunit/assembly factors; MGST3 and MGST2 are mitochondrial/microsomal glutathione S-transferases involved in oxidative stress defense; POMP is the proteasome maturation protein required for 20S assembly; LAMTOR1 and LAMTOR2 are core Ragulator complex subunits anchoring mTORC1 to lysosomes; TXNL4A is a thioredoxin-like spliceosome component; SRSF9 is a splicing factor; RABAC1 (Yip1A) regulates ER-Golgi trafficking; TMEM106C is a lysosomal membrane protein; VSIG2 is a cell adhesion molecule. The module integrates Complex I, lysosomal mTORC1 signaling (Ragulator), and proteasome maturation — a mitochondria-lysosome-proteasome housekeeping axis. Neighbor context with M1 (proteasome) and M65 (Complex IV) strongly supports this interpretation.
Genes
Most correlated modules
- Proteasome Proteolysis · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Membrane Trafficking · correlation 0.99
- Organelle Homeostasis · correlation 0.99
- Epithelial Identity · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.