Housekeeping Mixed
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SNRPB2 and SNRPD3 (snRNP/spliceosome components), PSMB6 (proteasome subunit), PPIB (peptidyl-prolyl isomerase/chaperone), PTGES3 (co-chaperone/prostaglandin synthase), MRPS36 (mitochondrial ribosomal protein), CNBP (RNA-binding zinc finger protein), TMEM14B (mitochondrial membrane), and SCP2 (lipid transfer). The module is uniformly expressed, all genes are core members, and the pattern of decreased expression in inflammation with recovery upon CD treatment suggests these are housekeeping/constitutive cellular maintenance genes. The mix includes RNA splicing (SNRPB2, SNRPD3), protein folding (PPIB, PTGES3), proteasome (PSMB6), and mitochondrial components — a classic housekeeping signature. Neighbor modules share similar housekeeping themes (splicing, OxPhos, translation), reinforcing this interpretation.
Genes
Most correlated modules
- Proteasome Proteolysis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- Protein Homeostasis · correlation 0.99
- Protein Processing ER · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
- Chaperone Proteostasis · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.