OxPhos Complex IV
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
NDUFA4 and HIGD2A are Complex IV (cytochrome c oxidase) subunit/assembly factors; ATP5MF is an ATP synthase subunit; CYB5A is cytochrome b5 involved in electron transfer at ER and mitochondria; SSR2 and OST4 are components of the translocon-associated protein (TRAP) complex and oligosaccharyltransferase at the ER; BTF3 is a transcription factor also associated with nascent polypeptide-associated complex; RNF7 is a RING-domain E3 ubiquitin ligase (CRL4); BRI3 is a membrane protein. The dominant theme is mitochondrial OxPhos (Complex IV) combined with ER membrane protein biogenesis. Neighbor modules M1 and M53 reinforce a housekeeping/OxPhos neighborhood.
Genes
Most correlated modules
- ER Cotranslational Processing · correlation 1.00
- Proteasome Proteolysis · correlation 0.99
- Oxidative Phosphorylation · correlation 0.99
- Epithelial Identity · correlation 0.99
- Complex I Assembly · correlation 0.99
- Colonocyte Differentiation · correlation 0.99
- Organelle Homeostasis · correlation 0.99
- Membrane Trafficking · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.