Colonocyte Epithelial
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
GUCY2C (guanylate cyclase C) is the receptor for guanylin/uroguanylin and is a highly specific marker of intestinal epithelial cells, particularly colonocytes. TJP1 (ZO-1) is a canonical tight junction scaffolding protein. CXADR (coxsackievirus and adenovirus receptor) is an epithelial tight junction protein. IL6ST (gp130) is the shared signal transducer for IL-6 family cytokines. EFNB2 (ephrin-B2) is involved in epithelial cell positioning and crypt-villus axis signaling. PRKAR1A is the regulatory subunit of PKA, downstream of GUCY2C/cGMP signaling. TMEM106B is a lysosomal membrane protein. PAK2 is a serine/threonine kinase involved in cytoskeletal regulation. The combination of GUCY2C, TJP1, and CXADR strongly indicates mature colonocyte identity, possibly representing contaminating colonocyte signal or a shared epithelial program in M-like cells.
Genes
Most correlated modules
- Macrophage Homeostasis · correlation 0.99
- Growth Arrest Stress · correlation 0.98
- Autophagy Lysosomal · correlation 0.98
- Absorptive Enterocyte · correlation 0.98
- Actin Cytoskeletal Regulation · correlation 0.98
- Non-canonical NF-κB · correlation 0.97
- Lysosomal Lipid Catabolism · correlation 0.96
- Stress Survival Response · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.