Macrophage Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include IFNGR2 (IFN-γ receptor signaling), NFE2L3 (NRF-family oxidative stress TF), HEPH (iron oxidase/metabolism), FUCA1 (lysosomal fucosidase), MUC13 (mucin/epithelial surface), MPZL1 (immune signaling adaptor), SNX6 (endosomal sorting), PALLD (cytoskeletal scaffold), RCN1 (ER calcium), ABHD17C (palmitoylation). The module is uniformly expressed with no subset enrichment, moderate mean expression, and no significant disease association. The combination of immune receptor (IFNGR2), lysosomal enzyme (FUCA1), mucin (MUC13), and metabolic/ER genes suggests a broad macrophage-like homeostatic program rather than a single tight pathway. IFNGR2 and NFE2L3 provide the strongest thematic anchor toward immune-metabolic homeostasis in M-like cells.
Genes
Most correlated modules
- Lysosomal Lipid Catabolism · correlation 0.99
- Autophagy Lysosomal · correlation 0.99
- Colonocyte Epithelial · correlation 0.99
- Absorptive Enterocyte · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.98
- ER Redox Homeostasis · correlation 0.98
- Growth Arrest Stress · correlation 0.98
- Non-canonical NF-κB · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.