Autophagy Lysosomal
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
MAP1LC3B is the canonical autophagosome marker (LC3B), directly involved in autophagy. PSAP (prosaposin) is a lysosomal protein essential for sphingolipid degradation. APLP2 (amyloid precursor-like protein 2) is involved in vesicular trafficking and has roles in autophagy regulation. CHP1 (calcineurin-like EF-hand protein) regulates NHE1 and vesicular pH. GOLM1 (Golgi membrane protein 1) is a Golgi-resident protein involved in vesicular trafficking. CYB5R3 (cytochrome b5 reductase 3) is involved in lipid desaturation and methemoglobin reduction. YWHAH (14-3-3 eta) regulates autophagy and apoptosis signaling. TOP1 (topoisomerase I) is a housekeeping nuclear enzyme. The convergence of MAP1LC3B, PSAP, APLP2, and GOLM1 strongly supports an autophagy/lysosomal trafficking program.
Genes
Most correlated modules
- Macrophage Homeostasis · correlation 0.99
- Actin Cytoskeletal Regulation · correlation 0.99
- Stress Survival Response · correlation 0.99
- Growth Arrest Stress · correlation 0.98
- Macrophage Phagocytic · correlation 0.98
- Colonocyte Epithelial · correlation 0.98
- Non-canonical NF-κB · correlation 0.98
- Inflammatory Myeloid · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.