Non-canonical NF-κB
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include ITGAM (CD11b, canonical macrophage integrin), RELB (non-canonical NF-κB transcription factor), NECTIN1 (cell adhesion), ARPC1B (Arp2/3 actin branching complex), ARHGAP18 (Rho GTPase-activating protein), and PTTG1IP (adhesion/migration). Together these reflect macrophage surface identity, non-canonical NF-κB activation, and actin-mediated adhesion/migration programs characteristic of tissue-resident macrophage states.
Genes
Most correlated modules
- Vesicle Membrane Trafficking · correlation 0.99
- Macrophage Homeostasis · correlation 0.98
- WNT-BMP Morphogenic · correlation 0.98
- Stress Survival Response · correlation 0.98
- Autophagy Lysosomal · correlation 0.98
- Lysosomal Lipid Catabolism · correlation 0.98
- Phagocytic Lipid Catabolism · correlation 0.97
- Absorptive Enterocyte · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.