Actin Cytoskeletal Regulation
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes CAPZA1, CAPZA2, ACTR2 (Arp2/3 complex subunit), COTL1 (coactosin-like actin-binding), and CTNNA1 (alpha-catenin, actin-cadherin linker) collectively define an actin cytoskeletal regulation program. Supporting genes TMEM176A, TNIP1, and BHLHE41 indicate this occurs in homeostatic/anti-inflammatory macrophage-like cells. LRP10 contributes vesicular trafficking. All genes are core members with uniform expression, consistent with a constitutive cytoskeletal program in resident M_like cells rather than an activation or stress response.
Genes
Most correlated modules
- Autophagy Lysosomal · correlation 0.99
- Growth Arrest Stress · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Macrophage Phagocytic · correlation 0.98
- Colonocyte Epithelial · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Stress Survival Response · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.