Lysosomal Lipid Catabolism
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
NPC2 (Niemann-Pick C2) is a lysosomal cholesterol-binding protein critical for intracellular cholesterol trafficking; mutations cause lysosomal lipid storage disease. CTSZ (cathepsin Z) is a lysosomal cysteine protease expressed in macrophages. LITAF (LPS-induced TNF-alpha factor) is a lysosomal membrane protein involved in inflammatory signaling and protein degradation. HEBP1 (heme-binding protein 1) is involved in heme catabolism. CHPT1 (choline phosphotransferase 1) synthesizes phosphatidylcholine in the ER. ARL6IP5 is a membrane-associated protein involved in glutamate transport and apoptosis. ABRACL modulates actin dynamics. The module shows significant upregulation in UC inflammation and significant reduction with CD treatment, suggesting an inflammation-responsive lysosomal/lipid catabolism program in macrophage-like cells.
Genes
Most correlated modules
- Macrophage Homeostasis · correlation 0.99
- Inflammatory Myeloid · correlation 0.99
- Absorptive Enterocyte · correlation 0.99
- ER Redox Homeostasis · correlation 0.99
- WNT-BMP Morphogenic · correlation 0.99
- Sphingolipid Membrane Organization · correlation 0.98
- Non-canonical NF-κB · correlation 0.98
- Macrophage Phagocytic · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.