Absorptive Enterocyte
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
SLC5A1 (SGLT1) is the canonical apical glucose/galactose transporter of absorptive enterocytes and is one of the strongest markers of mature absorptive colonocytes. F11R (JAM-A) is a tight junction protein enriched in epithelial cells. TMEM30A is a phospholipid flippase subunit important for membrane asymmetry in epithelial cells. ABCD3 is a peroxisomal ABC transporter involved in fatty acid oxidation. RAB9A mediates late endosome-to-TGN trafficking. CMTM6 regulates PD-L1 stability. LIMS1 (PINCH-1) is an integrin-linked kinase adaptor. GLO1 detoxifies methylglyoxal. SERINC1 incorporates serine into lipids. The presence of SLC5A1 and F11R as core members strongly suggests this module reflects absorptive enterocyte-associated gene expression, possibly representing contaminating absorptive colonocyte signal in M-like cells or a shared absorptive program.
Genes
Most correlated modules
- Lysosomal Lipid Catabolism · correlation 0.99
- Macrophage Homeostasis · correlation 0.98
- Sphingolipid Membrane Organization · correlation 0.98
- Colonocyte Epithelial · correlation 0.98
- ER Redox Homeostasis · correlation 0.97
- WNT-BMP Morphogenic · correlation 0.97
- Non-canonical NF-κB · correlation 0.97
- Phagocytic Lipid Catabolism · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.