Protein Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include CKAP4 (cytoskeleton-associated protein/ER membrane), UBE2L3 (ubiquitin-conjugating enzyme), DSG2 (desmosomal cadherin), PSMA5 (proteasome subunit), VDAC3 (mitochondrial outer membrane channel), CANX (calnexin, ER chaperone), GDI2 (GDP dissociation inhibitor), CCT5 (chaperonin complex), and CD164 (sialomucin). All genes are uniformly expressed and core members. The module combines protein quality control (PSMA5, UBE2L3, CANX, CCT5), membrane/ER organization (CKAP4, CANX), and housekeeping cell maintenance functions. The consistent downregulation during inflammation (UC and CD) and recovery with CD treatment suggests these are constitutive homeostatic programs suppressed in disease. This is a general housekeeping/protein homeostasis module. Concordant housekeeping/protein homeostasis genes: CKAP4, UBE2L3, PSMA5, CANX, CCT5, VDAC3, GDI2, DSG2, DCTPP1, CD164.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Protein Processing ER · correlation 0.99
- DNA Damage Response · correlation 0.99
- ER Membrane Trafficking · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Apoptosis Regulation · correlation 0.99
- Membrane Trafficking · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.