Epithelial Identity
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB25 (epithelial vesicle trafficking), EPCAM (epithelial cell adhesion molecule), PDLIM1 (epithelial cytoskeletal scaffold), LGALS3 (galectin-3, epithelial), NANS (sialic acid biosynthesis), CHMP2A (ESCRT/endosomal sorting), MYL12A (myosin), SKP1 (SCF ubiquitin ligase). All genes are uniformly expressed and core members. The module captures general epithelial identity and housekeeping functions. Decreased in CD inflammation consistent with epithelial loss.
Genes
Most correlated modules
- Colonocyte Differentiation · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Membrane Trafficking · correlation 0.99
- Macrophage Phagocytic · correlation 0.99
- Complex I Assembly · correlation 0.99
- Macrophage Homeostasis · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.99
- Metabolic Detoxification · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.