Organelle Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include C1orf43 (conserved protein, ribosome biogenesis/housekeeping), SUMO2 (small ubiquitin-like modifier, protein SUMOylation), ATP6V1G1 (V-ATPase subunit, lysosomal acidification), DECR1 (2,4-dienoyl-CoA reductase, mitochondrial fatty acid beta-oxidation), OSTC (oligosaccharyltransferase complex, N-glycosylation in ER), BRK1 (BRICK1, Arp2/3 complex activator, actin branching), SDHC (succinate dehydrogenase subunit C, mitochondrial complex II), PAPOLA (poly(A) polymerase alpha, mRNA polyadenylation), IGFBP2 (insulin-like growth factor binding protein 2). All are core members with uniform expression. The module spans mitochondrial metabolism (DECR1, SDHC), ER/glycosylation (OSTC), protein modification (SUMO2), lysosomal function (ATP6V1G1), RNA processing (PAPOLA), and cytoskeletal regulation (BRK1). Like its neighbors, it is downregulated in inflammation and recovers with CD treatment, consistent with constitutive housekeeping. The mix of organelle maintenance functions across ER, mitochondria, and lysosomes defines this as a general organelle homeostasis module. Concordant genes: C1orf43, SUMO2, ATP6V1G1, DECR1, OSTC, BRK1, SDHC, PAPOLA, IGFBP2.
Genes
Most correlated modules
- Membrane Trafficking · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
- Translation Initiation · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- Intracellular Cargo Transport · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Complex I Assembly · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.