WNT-BMP Morphogenic
Gene co-expression module in Microfold-like cells
| Category | WNT pathway |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
FZD7 is a Frizzled WNT receptor; BMP7 is a TGF-β superfamily morphogen; DAAM1 is a formin downstream of WNT/PCP signaling; ALDH1A1 generates retinoic acid (a morphogenic signal); BCL2L1 promotes survival; CTSE (cathepsin E) is a lysosomal protease; SNX10 mediates endosomal sorting; TBXAS1 produces thromboxane A2. The co-expression of WNT receptor FZD7, BMP7, and DAAM1 alongside ALDH1A1 suggests a morphogenic/tissue-remodeling program in macrophages, potentially reflecting a regulatory macrophage state involved in tissue homeostasis.
Genes
Most correlated modules
- Lysosomal Lipid Catabolism · correlation 0.99
- Sphingolipid Membrane Organization · correlation 0.99
- Non-canonical NF-κB · correlation 0.98
- Phagocytic Lipid Catabolism · correlation 0.97
- Absorptive Enterocyte · correlation 0.97
- Macrophage Homeostasis · correlation 0.97
- Tissue-protective Macrophage · correlation 0.97
- Inflammatory Myeloid · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.