Oxidative Phosphorylation
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Module is dominated by mitochondrial respiratory chain subunits: COX4I1, COX6A1, COX8A (Complex IV/cytochrome c oxidase), NDUFB1, NDUFB11 (Complex I/NADH dehydrogenase), UQCR10 (Complex III), ATP5MC2, ATP5PD (Complex V/ATP synthase), TOMM7 (mitochondrial outer membrane translocase). MRPL52 is a mitochondrial ribosomal protein. HINT1 and UXT are minor members. NACA is a nascent polypeptide-associated complex alpha. This is a tight, coherent OxPhos module. Decreased in UC inflammation reflects reduced mitochondrial activity in inflamed epithelium.
Genes
Most correlated modules
- OxPhos & Mitochondrial · correlation 0.99
- Colonocyte Differentiation · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.99
- ER Cotranslational Processing · correlation 0.99
- Epithelial Metabolic Housekeeping · correlation 0.99
- Chaperone Proteostasis · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.