Colonocyte Differentiation
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
CDX1 is a master intestinal transcription factor defining colonocyte identity. FAM3D is an intestinal-secreted cytokine-like factor. NDUFB8 and NDUFA5 are Complex I subunits (OxPhos, shared with M105 neighbor). ERP29 is an ER luminal protein involved in secretory protein folding. SRP14 is part of the signal recognition particle for ER targeting. TSPO is a mitochondrial translocator protein. CLIC1 is a chloride channel. CD9 is a tetraspanin expressed on epithelial cells. EIF4E2 is a translation initiation factor. PFN1 is profilin (cytoskeletal). The module blends intestinal epithelial identity (CDX1, FAM3D) with mitochondrial and ER components, consistent with a colonocyte differentiation state program. Neighbor M105 shares OxPhos genes, supporting the mitochondrial component here.
Genes
Most correlated modules
- Metabolic Detoxification · correlation 0.99
- Oxidative Phosphorylation · correlation 0.99
- Epithelial Identity · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Epithelial Metabolic Housekeeping · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.99
- ER Protein Folding · correlation 0.98
- Chaperone Proteostasis · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.