ER Protein Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include MLEC (malectin, ER lectin for glycoprotein folding), RBM3 (cold-shock RNA-binding protein, stress-responsive), HNRNPA3 (heterogeneous nuclear ribonucleoprotein, RNA processing), ECHS1 (mitochondrial fatty acid beta-oxidation), TRIR (telomerase RNA component interacting), SELENOS (ER selenoprotein, redox/ER stress), CSNK2B (casein kinase 2 regulatory subunit), ATP1A1 (Na/K-ATPase). The combination of ER-resident proteins (MLEC, SELENOS), RNA-binding proteins (RBM3, HNRNPA3), and metabolic enzymes suggests a general housekeeping/ER homeostasis program. Downregulated in inflammation, partially restored with CD treatment. Neighbor context (metabolic/housekeeping modules) supports a housekeeping classification. SELENOS and MLEC point specifically to ER protein quality control.
Genes
Most correlated modules
- Oxidative Stress Response · correlation 0.99
- Chaperone Proteostasis · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Inflammatory Activation Stress · correlation 0.98
- Antigen Presentation Housekeeping · correlation 0.98
- ER Protein Folding · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.