Metabolic Detoxification
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
AKR1A1 (aldo-keto reductase 1A1, detoxification/carbonyl reduction), TST (thiosulfate sulfurtransferase, mitochondrial sulfur metabolism), DBI (diazepam binding inhibitor/acyl-CoA binding protein, lipid metabolism and mitochondria), UQCR11 (Complex III subunit, OxPhos — shared with M105 neighbor), S100A10 (calcium-binding, membrane repair), MYL12B (myosin light chain, cytoskeletal), MARCKSL1 (membrane-cytoskeletal linker), SSR4 (signal sequence receptor delta, ER translocation), ITM2C (integral membrane protein 2C), HLA-C (MHC class I), UBL5 (ubiquitin-like), PRR13 (proline-rich), PFDN5 (prefoldin chaperone), CIB1 (calcium/integrin binding). This is a mixed housekeeping module combining metabolic detoxification, mitochondrial, ER, and cytoskeletal elements. The presence of HLA-C is notable but isolated. The module likely represents a general epithelial metabolic/proteostasis state.
Genes
Most correlated modules
- Colonocyte Differentiation · correlation 0.99
- Epithelial Metabolic Housekeeping · correlation 0.99
- Epithelial Identity · correlation 0.99
- ER Protein Folding · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Macrophage Phagocytic · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.