Hypoxia Response Regulation
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include CDHR1 (cadherin-related family member, photoreceptor/epithelial), CITED2 (CBP/p300-interacting transactivator, HIF pathway coregulator), TRIM31 (E3 ubiquitin ligase, innate immune signaling), DST (dystonin/BPAG1, cytoskeletal linker), CHD3 (chromodomain helicase, NuRD complex), DLGAP4 (membrane-associated guanylate kinase), WSB1 (SOCS box protein, ubiquitin ligase adaptor, HIF-1α regulation), SOX8 (SRY-box transcription factor). CITED2 and WSB1 are both HIF pathway regulators (CITED2 inhibits HIF-1α; WSB1 promotes HIF-1α stability), suggesting a hypoxia-response regulatory module. The significant increase with CD inflammation supports activation under inflammatory/hypoxic conditions in the colon.
Genes
Most correlated modules
- Inflammatory Lipid Metabolism · correlation 0.99
- Macrophage Identity Adhesion · correlation 0.98
- Macrophage Transcriptional Regulation · correlation 0.97
- BMP-ID Stress Response · correlation 0.97
- Proteasome & Apoptosis · correlation 0.96
- RNA Processing Translation · correlation 0.94
- Desmosomal Adhesion · correlation 0.90
- Housekeeping Metabolism · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.