Inflammatory Lipid Metabolism
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include HK2 (hexokinase 2, glycolysis), PFKFB3 (key glycolytic regulator, hypoxia-inducible), ALOX5 (arachidonate 5-lipoxygenase, leukotriene synthesis), PLA2G10 (phospholipase A2, lipid mediator release), GNAQ and PLCB4 (Gq/PLC signaling), RYBP (Polycomb repressor), CFDP1 (chromatin organization), UBE2W (ubiquitin E2), RNF125 (E3 ubiquitin ligase), PDLIM5 (cytoskeletal LIM domain), UGT2A3 (UDP-glucuronosyltransferase), COL11A2 (collagen). The glycolytic enzymes HK2 and PFKFB3 together with ALOX5 and PLA2G10 suggest a pro-inflammatory lipid mediator and glycolytic reprogramming program, consistent with inflammatory macrophage activation. The trend toward increase with inflammation (UC and CD) supports this interpretation.
Genes
Most correlated modules
- Macrophage Identity Adhesion · correlation 0.99
- Hypoxia Response Regulation · correlation 0.99
- Macrophage Transcriptional Regulation · correlation 0.99
- Proteasome & Apoptosis · correlation 0.99
- BMP-ID Stress Response · correlation 0.96
- RNA Processing Translation · correlation 0.96
- Desmosomal Adhesion · correlation 0.91
- Housekeeping Metabolism · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.