RNA Processing Translation
Gene co-expression module in Microfold-like cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include SERBP1 (SERPINE1 mRNA binding protein, RNA stability), SNRPD2 (snRNP, spliceosome), RBM8A (exon junction complex), CSDE1 (RNA binding, translation regulation), EIF3A (translation initiation), HMGN2 (chromatin/nucleosome remodeling), NEDD8 (neddylation, protein modification), SEM1 (26S proteasome regulatory subunit), CYC1 (cytochrome c1, mitochondrial respiratory chain), ECH1 (mitochondrial enoyl-CoA hydratase), ARF1 (vesicle trafficking GTPase), HSBP1 (heat shock factor binding), ATF3 (stress-responsive transcription factor), PEBP1 (Raf kinase inhibitor), APRT (purine salvage), NTRK2 (BDNF receptor). The module is dominated by RNA processing (SERBP1, SNRPD2, RBM8A, CSDE1, EIF3A) and general housekeeping functions. The significant decrease with UC inflammation suggests these baseline cellular functions are suppressed in inflamed macrophages.
Genes
Most correlated modules
- Proteasome & Apoptosis · correlation 0.99
- BMP-ID Stress Response · correlation 0.98
- Macrophage Identity Adhesion · correlation 0.97
- Macrophage Transcriptional Regulation · correlation 0.97
- Inflammatory Lipid Metabolism · correlation 0.96
- Hypoxia Response Regulation · correlation 0.94
- Desmosomal Adhesion · correlation 0.93
- Housekeeping Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.