Housekeeping Metabolism
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 19 genes have a known function matching the annotation |
Why this annotation
The module contains multiple mitochondrial/OxPhos genes (SLC25A6, ATP5IF1, COX6B1, CYCS, ATP5PF), translation factors (EEF2, PABPC1, TMA7, EIF3K, EIF1), and general housekeeping genes (PPIA, CALR, GSTP1). The module is significantly downregulated in both UC and CD inflammation, consistent with suppression of basal metabolic/housekeeping programs during inflammatory states. The mix of mitochondrial and translational components suggests a general cellular housekeeping/metabolic maintenance program rather than a single focused pathway.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.93
- Desmosomal Adhesion · correlation 0.91
- Actin Cytoskeletal Dynamics · correlation 0.90
- BMP-ID Stress Response · correlation 0.89
- Macrophage Identity Adhesion · correlation 0.86
- Proteasome & Apoptosis · correlation 0.86
- Macrophage Transcriptional Regulation · correlation 0.82
- Inflammatory Lipid Metabolism · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.