Macrophage Identity Adhesion
Gene co-expression module in Microfold-like cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include TCF12 (E-protein transcription factor involved in lineage specification), CD47 (don't-eat-me signal, immune checkpoint), VCL (vinculin, focal adhesion), HOOK1 (cytoskeletal linker/endosomal trafficking), ST14 (matriptase, epithelial serine protease), SH3BGRL and SH3YL1 (SH3 domain proteins, signaling scaffolds), PNRC1 (proline-rich nuclear receptor coactivator), MYADM (myeloid-associated differentiation marker). The combination of CD47 (macrophage immune evasion signal), MYADM (myeloid differentiation), TCF12 (transcriptional regulation of immune lineage), and VCL (adhesion) points to a macrophage identity/adhesion program. The significant decrease with CD treatment suggests this program is suppressed upon therapeutic intervention.
Genes
Most correlated modules
- Inflammatory Lipid Metabolism · correlation 0.99
- Proteasome & Apoptosis · correlation 0.99
- Hypoxia Response Regulation · correlation 0.98
- RNA Processing Translation · correlation 0.97
- Macrophage Transcriptional Regulation · correlation 0.97
- BMP-ID Stress Response · correlation 0.97
- Desmosomal Adhesion · correlation 0.95
- Housekeeping Metabolism · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.