Proteasome & Apoptosis
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSMC1 and PSMD8 (proteasome 26S subunits), CALM3 (calmodulin, calcium signaling), RAB11A (endosomal recycling GTPase), ARPC1A (Arp2/3 actin branching), PDCD6 (apoptosis-linked calcium sensor), TNFSF10 (TRAIL, apoptosis inducer), TRAM1 (ER translocation), TSPAN1 (tetraspanin), and ERH (RNA processing). The module combines proteasomal degradation machinery with calcium-dependent apoptosis signaling (CALM3, PDCD6, TNFSF10) and vesicular trafficking (RAB11A). The dominant theme is ubiquitin-proteasome-mediated protein degradation coupled to apoptotic signaling, consistent with macrophage-like cell proteostasis and death-receptor pathway activity. The significant increase with CD treatment is consistent with resolution of inflammatory macrophage states.
Genes
Most correlated modules
- Macrophage Transcriptional Regulation · correlation 0.99
- Macrophage Identity Adhesion · correlation 0.99
- RNA Processing Translation · correlation 0.99
- Inflammatory Lipid Metabolism · correlation 0.99
- BMP-ID Stress Response · correlation 0.97
- Hypoxia Response Regulation · correlation 0.96
- Desmosomal Adhesion · correlation 0.92
- Housekeeping Metabolism · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.