Desmosomal Adhesion
Gene co-expression module in Microfold-like cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes DSC2 (desmocollin-2), PERP (desmosomal p53 effector), FERMT1 (kindlin-1, epithelial integrin), KRT8 (keratin), and ICAM2 collectively define an epithelial desmosomal adhesion program. ST6GALNAC1 adds epithelial glycosylation, LEFTY1 reflects epithelial differentiation signaling, and GLRX contributes redox regulation. The module is upregulated in UC inflammation, consistent with epithelial stress/remodeling. All genes show uniform expression across subsets, suggesting a broadly active epithelial integrity program in M_like cells (possibly reflecting phagocytosed epithelial material or a macrophage-epithelial crosstalk state).
Genes
Most correlated modules
- Macrophage Identity Adhesion · correlation 0.95
- RNA Processing Translation · correlation 0.93
- Proteasome & Apoptosis · correlation 0.92
- Housekeeping Metabolism · correlation 0.91
- Inflammatory Lipid Metabolism · correlation 0.91
- Hypoxia Response Regulation · correlation 0.90
- BMP-ID Stress Response · correlation 0.90
- Macrophage Transcriptional Regulation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.