Macrophage Transcriptional Regulation
Gene co-expression module in Microfold-like cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include IRF2BP2 (transcriptional repressor of inflammatory genes, macrophage polarization regulator), MAP3K13 (MAPK kinase kinase, stress/NF-kB signaling), THRAP3 (thyroid hormone receptor-associated, transcriptional coregulator), NFIA and NFIC (NFI family transcription factors, chromatin remodeling), NAMPT (PBEF/visfatin, NAD biosynthesis, inflammatory cytokine), CD44 (adhesion/stemness marker), SERPINB6 (serine protease inhibitor), STOML2 (mitochondrial stomatin), APEX1 (DNA repair), CCND1 (cyclin D1, cell cycle G1/S), RBMX (RNA binding), NFIC (transcription factor), GNPTAB (lysosomal enzyme targeting). The combination of IRF2BP2, NFIA/NFIC, NAMPT, and CD44 points to a transcriptional regulatory program governing macrophage inflammatory state and metabolic reprogramming. Significant increase with CD treatment suggests restoration of homeostatic transcriptional control.
Genes
Most correlated modules
- Proteasome & Apoptosis · correlation 0.99
- Inflammatory Lipid Metabolism · correlation 0.99
- BMP-ID Stress Response · correlation 0.98
- Macrophage Identity Adhesion · correlation 0.97
- RNA Processing Translation · correlation 0.97
- Hypoxia Response Regulation · correlation 0.97
- Desmosomal Adhesion · correlation 0.87
- Housekeeping Metabolism · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.